国际安保专家高皓军(刘德华 饰)搭乘有“空中巨无霸”之称的特大豪华客机A380首航,途中遭遇暴徒劫机。无差别射杀让豪华机舱瞬间变成密闭炼狱,800余名乘客危在旦夕。高皓军挺身而出与暴徒周旋,他不知道,藏在人质中与他里应外合的“小帮手”,正是自己已经失明的女儿小军(张子枫 饰)……数千米高空之上,这对父女将怎样化解一场惊天危机?Gao Haojun, an international security expert, is hijacked by gunmen on the first flight of A380 airliner, and his blind daughter is one of the undercover hostages, a fact that he doesn't know.